hrp0084p3-968 | GH & IGF | ESPE2015

Bone Age Maturation in Prader-Willi Syndrome on GH Treatment is Accelerated in Pre-Pubertal Age without Affecting Final Height

Eiholzer Urs , Obwegeser Carla , Witassek Fabienne , Meinhardt Udo

Background: In children with Prader-Willi Syndrome (PWS) on Growth Hormone treatment (GHT) bone age (BA) acceleration is often observed. Little is known on reasons and consequences.Objective and hypotheses: To quantify BA acceleration in pre-pubertal PWS children on GHT and to investigate how BA correlates with weight gain and age at onset of GHT. To assess how final height depends on pre-pubertal bone maturation, weight gain and age at onset of GHT....